This paper presents the development rationale of a novel VR educational application based on the evaluation of the user requirements by 405 pharmacy undergraduate students. This reduces students’ interest and concentration in the taught subjects. However, current educational efforts employing VR offer limited interactivity and a traditional teaching method previously presented in 2D. Contemporary studies have presented Virtual Reality (VR) as an alternative method for improving the learning and teaching of multidisciplinary specialties such as this. Chemical and pharmacological principles are typically presented in 2D molecular structures and, recently, 3D molecular models have been utilized to improve the visualization of chemical compounds and their chemical interactions. This combination of applied and basic science creates a complex field of education that is challenging to both teach and learn. This study focused on the subject of medicinal chemistry, which is a discipline combining medicine and chemistry.

Such topics can deter students from selecting particular courses or hinder their study progress. Multidisciplinary topics in education pose a major challenge for traditional learning and teaching methods.

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